Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model
Identifieur interne : 002447 ( Main/Exploration ); précédent : 002446; suivant : 002448Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model
Auteurs : Yohichi Kumaki [États-Unis] ; Jane Ennis [Canada] ; Ramtin Rahbar [Canada] ; Jeffrey D. Turner [Canada] ; Miles K. Wandersee [États-Unis] ; Aaron J. Smith [États-Unis] ; Kevin W. Bailey [États-Unis] ; Zachary G. Vest [États-Unis] ; Jason R. Madsen [États-Unis] ; Joseph K.-K. Li [États-Unis] ; Dale L. Barnard [États-Unis]Source :
- Antiviral Research [ 0166-3542 ] ; 2010.
Descripteurs français
- KwdFr :
- Adenoviridae (génétique), Administration par voie nasale, Analyse de survie, Animaux, Antiviraux (administration et posologie), Antiviraux (immunologie), Cellules Vero, Femelle, Humains, Interféron alpha (administration et posologie), Interféron alpha (génétique), Interféron alpha (immunologie), Modèles animaux de maladie humaine, Poids du corps, Produits biologiques (administration et posologie), Produits biologiques (génétique), Produits biologiques (immunologie), Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (mortalité), Vecteurs génétiques, Virus du SRAS (immunologie).
- MESH :
- administration et posologie : Antiviraux, Interféron alpha, Produits biologiques.
- anatomopathologie : Syndrome respiratoire aigu sévère.
- génétique : Adenoviridae, Interféron alpha, Produits biologiques.
- immunologie : Antiviraux, Interféron alpha, Produits biologiques, Virus du SRAS.
- mortalité : Syndrome respiratoire aigu sévère.
- Administration par voie nasale, Analyse de survie, Animaux, Cellules Vero, Femelle, Humains, Modèles animaux de maladie humaine, Poids du corps, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère, Vecteurs génétiques.
English descriptors
- KwdEn :
- Adenoviridae (genetics), Administration, Intranasal, Animals, Antiviral Agents (administration & dosage), Antiviral Agents (immunology), Biological Products (administration & dosage), Biological Products (genetics), Biological Products (immunology), Body Weight, Chlorocebus aethiops, Disease Models, Animal, Female, Genetic Vectors, Humans, Interferon-alpha (administration & dosage), Interferon-alpha (genetics), Interferon-alpha (immunology), Mice, Mice, Inbred BALB C, SARS Virus (immunology), Severe Acute Respiratory Syndrome (mortality), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (prevention & control), Survival Analysis, Vero Cells.
- MESH :
- chemical , administration & dosage : Antiviral Agents, Biological Products, Interferon-alpha.
- genetics : Adenoviridae, Biological Products, Interferon-alpha.
- chemical , immunology : Antiviral Agents, Biological Products, Interferon-alpha, SARS Virus.
- mortality : Severe Acute Respiratory Syndrome.
- pathology : Severe Acute Respiratory Syndrome.
- prevention & control : Severe Acute Respiratory Syndrome.
- Administration, Intranasal, Animals, Body Weight, Chlorocebus aethiops, Disease Models, Animal, Female, Genetic Vectors, Humans, Mice, Mice, Inbred BALB C, Survival Analysis, Vero Cells.
Abstract
Interferons (IFNs) are a first line of defense against viral infection. Herein we describe the use of an adenovirus vectored mouse IFN alpha gene (mDEF201) as a prophylactic and treatment countermeasure in a SARS-CoV-infected BALB/c mouse model. Complete survival protection was observed in mice given a single dose of mDEF201 administered intranasally 1, 3, 5, 7, or 14 days prior to lethal SARS-CoV challenge (
Url:
DOI: 10.1016/j.antiviral.2010.11.007
PubMed: 21093489
PubMed Central: 3018546
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000D87
- to stream Pmc, to step Curation: 000D87
- to stream Pmc, to step Checkpoint: 000B86
- to stream PubMed, to step Corpus: 001584
- to stream PubMed, to step Curation: 001584
- to stream PubMed, to step Checkpoint: 001426
- to stream Ncbi, to step Merge: 002258
- to stream Ncbi, to step Curation: 002258
- to stream Ncbi, to step Checkpoint: 002258
- to stream Main, to step Merge: 002480
- to stream Main, to step Curation: 002447
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model</title><author><name sortKey="Kumaki, Yohichi" sort="Kumaki, Yohichi" uniqKey="Kumaki Y" first="Yohichi" last="Kumaki">Yohichi Kumaki</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Ennis, Jane" sort="Ennis, Jane" uniqKey="Ennis J" first="Jane" last="Ennis">Jane Ennis</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Defyrus Inc., 2 Bloor Street West, Suite 2602, Toronto, Ontario, Canada M4W 3E2</nlm:aff><country>Canada</country><wicri:regionArea>Defyrus Inc., 2 Bloor Street West, Suite 2602, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Rahbar, Ramtin" sort="Rahbar, Ramtin" uniqKey="Rahbar R" first="Ramtin" last="Rahbar">Ramtin Rahbar</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Defyrus Inc., 2 Bloor Street West, Suite 2602, Toronto, Ontario, Canada M4W 3E2</nlm:aff><country>Canada</country><wicri:regionArea>Defyrus Inc., 2 Bloor Street West, Suite 2602, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Turner, Jeffrey D" sort="Turner, Jeffrey D" uniqKey="Turner J" first="Jeffrey D." last="Turner">Jeffrey D. Turner</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Defyrus Inc., 2 Bloor Street West, Suite 2602, Toronto, Ontario, Canada M4W 3E2</nlm:aff><country>Canada</country><wicri:regionArea>Defyrus Inc., 2 Bloor Street West, Suite 2602, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Wandersee, Miles K" sort="Wandersee, Miles K" uniqKey="Wandersee M" first="Miles K." last="Wandersee">Miles K. Wandersee</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Smith, Aaron J" sort="Smith, Aaron J" uniqKey="Smith A" first="Aaron J." last="Smith">Aaron J. Smith</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Bailey, Kevin W" sort="Bailey, Kevin W" uniqKey="Bailey K" first="Kevin W." last="Bailey">Kevin W. Bailey</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Vest, Zachary G" sort="Vest, Zachary G" uniqKey="Vest Z" first="Zachary G." last="Vest">Zachary G. Vest</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Madsen, Jason R" sort="Madsen, Jason R" uniqKey="Madsen J" first="Jason R." last="Madsen">Jason R. Madsen</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Li, Joseph K K" sort="Li, Joseph K K" uniqKey="Li J" first="Joseph K.-K." last="Li">Joseph K.-K. Li</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Department of Biology, 5305 Old Main Hill, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, 5305 Old Main Hill, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Barnard, Dale L" sort="Barnard, Dale L" uniqKey="Barnard D" first="Dale L." last="Barnard">Dale L. Barnard</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21093489</idno><idno type="pmc">3018546</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018546</idno><idno type="RBID">PMC:3018546</idno><idno type="doi">10.1016/j.antiviral.2010.11.007</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000D87</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D87</idno><idno type="wicri:Area/Pmc/Curation">000D87</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D87</idno><idno type="wicri:Area/Pmc/Checkpoint">000B86</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B86</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:21093489</idno><idno type="wicri:Area/PubMed/Corpus">001584</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001584</idno><idno type="wicri:Area/PubMed/Curation">001584</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001584</idno><idno type="wicri:Area/PubMed/Checkpoint">001426</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001426</idno><idno type="wicri:Area/Ncbi/Merge">002258</idno><idno type="wicri:Area/Ncbi/Curation">002258</idno><idno type="wicri:Area/Ncbi/Checkpoint">002258</idno><idno type="wicri:doubleKey">0166-3542:2010:Kumaki Y:single:dose:intranasal</idno><idno type="wicri:Area/Main/Merge">002480</idno><idno type="wicri:Area/Main/Curation">002447</idno><idno type="wicri:Area/Main/Exploration">002447</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model</title><author><name sortKey="Kumaki, Yohichi" sort="Kumaki, Yohichi" uniqKey="Kumaki Y" first="Yohichi" last="Kumaki">Yohichi Kumaki</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Ennis, Jane" sort="Ennis, Jane" uniqKey="Ennis J" first="Jane" last="Ennis">Jane Ennis</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Defyrus Inc., 2 Bloor Street West, Suite 2602, Toronto, Ontario, Canada M4W 3E2</nlm:aff><country>Canada</country><wicri:regionArea>Defyrus Inc., 2 Bloor Street West, Suite 2602, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Rahbar, Ramtin" sort="Rahbar, Ramtin" uniqKey="Rahbar R" first="Ramtin" last="Rahbar">Ramtin Rahbar</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Defyrus Inc., 2 Bloor Street West, Suite 2602, Toronto, Ontario, Canada M4W 3E2</nlm:aff><country>Canada</country><wicri:regionArea>Defyrus Inc., 2 Bloor Street West, Suite 2602, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Turner, Jeffrey D" sort="Turner, Jeffrey D" uniqKey="Turner J" first="Jeffrey D." last="Turner">Jeffrey D. Turner</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Defyrus Inc., 2 Bloor Street West, Suite 2602, Toronto, Ontario, Canada M4W 3E2</nlm:aff><country>Canada</country><wicri:regionArea>Defyrus Inc., 2 Bloor Street West, Suite 2602, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Wandersee, Miles K" sort="Wandersee, Miles K" uniqKey="Wandersee M" first="Miles K." last="Wandersee">Miles K. Wandersee</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Smith, Aaron J" sort="Smith, Aaron J" uniqKey="Smith A" first="Aaron J." last="Smith">Aaron J. Smith</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Bailey, Kevin W" sort="Bailey, Kevin W" uniqKey="Bailey K" first="Kevin W." last="Bailey">Kevin W. Bailey</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Vest, Zachary G" sort="Vest, Zachary G" uniqKey="Vest Z" first="Zachary G." last="Vest">Zachary G. Vest</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Madsen, Jason R" sort="Madsen, Jason R" uniqKey="Madsen J" first="Jason R." last="Madsen">Jason R. Madsen</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Li, Joseph K K" sort="Li, Joseph K K" uniqKey="Li J" first="Joseph K.-K." last="Li">Joseph K.-K. Li</name><affiliation wicri:level="2"><nlm:aff id="aff0015">Department of Biology, 5305 Old Main Hill, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, 5305 Old Main Hill, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Barnard, Dale L" sort="Barnard, Dale L" uniqKey="Barnard D" first="Dale L." last="Barnard">Dale L. Barnard</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae (genetics)</term><term>Administration, Intranasal</term><term>Animals</term><term>Antiviral Agents (administration & dosage)</term><term>Antiviral Agents (immunology)</term><term>Biological Products (administration & dosage)</term><term>Biological Products (genetics)</term><term>Biological Products (immunology)</term><term>Body Weight</term><term>Chlorocebus aethiops</term><term>Disease Models, Animal</term><term>Female</term><term>Genetic Vectors</term><term>Humans</term><term>Interferon-alpha (administration & dosage)</term><term>Interferon-alpha (genetics)</term><term>Interferon-alpha (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (mortality)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Survival Analysis</term><term>Vero Cells</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae (génétique)</term><term>Administration par voie nasale</term><term>Analyse de survie</term><term>Animaux</term><term>Antiviraux (administration et posologie)</term><term>Antiviraux (immunologie)</term><term>Cellules Vero</term><term>Femelle</term><term>Humains</term><term>Interféron alpha (administration et posologie)</term><term>Interféron alpha (génétique)</term><term>Interféron alpha (immunologie)</term><term>Modèles animaux de maladie humaine</term><term>Poids du corps</term><term>Produits biologiques (administration et posologie)</term><term>Produits biologiques (génétique)</term><term>Produits biologiques (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (mortalité)</term><term>Vecteurs génétiques</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term><term>Biological Products</term><term>Interferon-alpha</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term><term>Interféron alpha</term><term>Produits biologiques</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviridae</term><term>Biological Products</term><term>Interferon-alpha</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adenoviridae</term><term>Interféron alpha</term><term>Produits biologiques</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antiviraux</term><term>Interféron alpha</term><term>Produits biologiques</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antiviral Agents</term><term>Biological Products</term><term>Interferon-alpha</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Body Weight</term><term>Chlorocebus aethiops</term><term>Disease Models, Animal</term><term>Female</term><term>Genetic Vectors</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Survival Analysis</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term><term>Analyse de survie</term><term>Animaux</term><term>Cellules Vero</term><term>Femelle</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Poids du corps</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère</term><term>Vecteurs génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Interferons (IFNs) are a first line of defense against viral infection. Herein we describe the use of an adenovirus vectored mouse IFN alpha gene (mDEF201) as a prophylactic and treatment countermeasure in a SARS-CoV-infected BALB/c mouse model. Complete survival protection was observed in mice given a single dose of mDEF201 administered intranasally 1, 3, 5, 7, or 14 days prior to lethal SARS-CoV challenge (<italic>p</italic> < 0.001), and body weights of these treated mice were unaffected by the challenge. In addition, low doses of mDEF201 protected lungs in a dose dependent manner as measured by a reduction in gross pathology. Intranasal treatment with mDEF201 ranging from 10<sup>6</sup> to 10<sup>8</sup> PFU significantly protected mice against a lethal SARS-CoV infection in a dose dependent manner up to 12 h post infection (<italic>p</italic> < 0.001). The data suggest that mDEF201 is a new class of antiviral agent further development as treatment for SARS-CoV infections.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ahlquist, P" uniqKey="Ahlquist P">P. Ahlquist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K. Anand</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author><author><name sortKey="Wadhwani, P" uniqKey="Wadhwani P">P. Wadhwani</name></author><author><name sortKey="Mesters, J R" uniqKey="Mesters J">J.R. Mesters</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnard, D L" uniqKey="Barnard D">D.L. Barnard</name></author><author><name sortKey="Kumaki, Y" uniqKey="Kumaki Y">Y. Kumaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnard, D L" uniqKey="Barnard D">D.L. Barnard</name></author><author><name sortKey="Day, C W" uniqKey="Day C">C.W. Day</name></author><author><name sortKey="Bailey, K" uniqKey="Bailey K">K. Bailey</name></author><author><name sortKey="Heiner, M" uniqKey="Heiner M">M. Heiner</name></author><author><name sortKey="Montgomery, R" uniqKey="Montgomery R">R. Montgomery</name></author><author><name sortKey="Lauridsen, L" uniqKey="Lauridsen L">L. Lauridsen</name></author><author><name sortKey="Chan, P K" uniqKey="Chan P">P.K. Chan</name></author><author><name sortKey="Sidwell, R W" uniqKey="Sidwell R">R.W. Sidwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bell, S J" uniqKey="Bell S">S.J. Bell</name></author><author><name sortKey="Fam, C M" uniqKey="Fam C">C.M. Fam</name></author><author><name sortKey="Chlipala, E A" uniqKey="Chlipala E">E.A. Chlipala</name></author><author><name sortKey="Carlson, S J" uniqKey="Carlson S">S.J. Carlson</name></author><author><name sortKey="Lee, J I" uniqKey="Lee J">J.I. Lee</name></author><author><name sortKey="Rosendahl, M S" uniqKey="Rosendahl M">M.S. Rosendahl</name></author><author><name sortKey="Doherty, D H" uniqKey="Doherty D">D.H. Doherty</name></author><author><name sortKey="Cox, G N" uniqKey="Cox G">G.N. Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blatt, L M" uniqKey="Blatt L">L.M. Blatt</name></author><author><name sortKey="Davis, J M" uniqKey="Davis J">J.M. Davis</name></author><author><name sortKey="Klein, S B" uniqKey="Klein S">S.B. Klein</name></author><author><name sortKey="Taylor, M W" uniqKey="Taylor M">M.W. Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J. Bosch</name></author><author><name sortKey="Martina, B E" uniqKey="Martina B">B.E. Martina</name></author><author><name sortKey="Van Der Zee, R" uniqKey="Van Der Zee R">R. Van Der Zee</name></author><author><name sortKey="Lepault, J" uniqKey="Lepault J">J. Lepault</name></author><author><name sortKey="Haijema, B J" uniqKey="Haijema B">B.J. Haijema</name></author><author><name sortKey="Versluis, C" uniqKey="Versluis C">C. Versluis</name></author><author><name sortKey="Heck, A J" uniqKey="Heck A">A.J. Heck</name></author><author><name sortKey="De Groot, R" uniqKey="De Groot R">R. De Groot</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Rottier, P J" uniqKey="Rottier P">P.J. Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brassard, D L" uniqKey="Brassard D">D.L. Brassard</name></author><author><name sortKey="Grace, M J" uniqKey="Grace M">M.J. Grace</name></author><author><name sortKey="Bordens, R W" uniqKey="Bordens R">R.W. Bordens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, Z" uniqKey="Chang Z">Z. Chang</name></author><author><name sortKey="Babiuk, L A" uniqKey="Babiuk L">L.A. Babiuk</name></author><author><name sortKey="Hu, J" uniqKey="Hu J">J. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, F" uniqKey="Chen F">F. Chen</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y. Jiang</name></author><author><name sortKey="Kao, R Y" uniqKey="Kao R">R.Y. Kao</name></author><author><name sortKey="Lu, H T" uniqKey="Lu H">H.T. Lu</name></author><author><name sortKey="Fan, K W" uniqKey="Fan K">K.W. Fan</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Tsui, W H" uniqKey="Tsui W">W.H. Tsui</name></author><author><name sortKey="Hung, I F" uniqKey="Hung I">I.F. Hung</name></author><author><name sortKey="Lee, T S" uniqKey="Lee T">T.S. Lee</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J. Cinatl</name></author><author><name sortKey="Morgenstern, B" uniqKey="Morgenstern B">B. Morgenstern</name></author><author><name sortKey="Bauer, G" uniqKey="Bauer G">G. Bauer</name></author><author><name sortKey="Chandra, P" uniqKey="Chandra P">P. Chandra</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Croyle, M A" uniqKey="Croyle M">M.A. Croyle</name></author><author><name sortKey="Patel, A" uniqKey="Patel A">A. Patel</name></author><author><name sortKey="Tran, K N" uniqKey="Tran K">K.N. Tran</name></author><author><name sortKey="Gray, M" uniqKey="Gray M">M. Gray</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Strong, J E" uniqKey="Strong J">J.E. Strong</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H. Feldmann</name></author><author><name sortKey="Kobinger, G P" uniqKey="Kobinger G">G.P. Kobinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dahl, H" uniqKey="Dahl H">H. Dahl</name></author><author><name sortKey="Linde, A" uniqKey="Linde A">A. Linde</name></author><author><name sortKey="Strannegard, O" uniqKey="Strannegard O">O. Strannegard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Day, C W" uniqKey="Day C">C.W. Day</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R. Baric</name></author><author><name sortKey="Cai, S X" uniqKey="Cai S">S.X. Cai</name></author><author><name sortKey="Frieman, M" uniqKey="Frieman M">M. Frieman</name></author><author><name sortKey="Kumaki, Y" uniqKey="Kumaki Y">Y. Kumaki</name></author><author><name sortKey="Morrey, J D" uniqKey="Morrey J">J.D. Morrey</name></author><author><name sortKey="Smee, D F" uniqKey="Smee D">D.F. Smee</name></author><author><name sortKey="Barnard, D L" uniqKey="Barnard D">D.L. Barnard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name></author><author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M. Panning</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L. Kolesnikova</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Berger, A" uniqKey="Berger A">A. Berger</name></author><author><name sortKey="Burguiere, A M" uniqKey="Burguiere A">A.M. Burguiere</name></author><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J. Cinatl</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name></author><author><name sortKey="Grywna, K" uniqKey="Grywna K">K. Grywna</name></author><author><name sortKey="Kramme, S" uniqKey="Kramme S">S. Kramme</name></author><author><name sortKey="Manuguerra, J C" uniqKey="Manuguerra J">J.C. Manuguerra</name></author><author><name sortKey="Muller, S" uniqKey="Muller S">S. Muller</name></author><author><name sortKey="Rickerts, V" uniqKey="Rickerts V">V. Rickerts</name></author><author><name sortKey="Sturmer, M" uniqKey="Sturmer M">M. Sturmer</name></author><author><name sortKey="Vieth, S" uniqKey="Vieth S">S. Vieth</name></author><author><name sortKey="Klenk, H D" uniqKey="Klenk H">H.D. Klenk</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H. Schmitz</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frantz, S" uniqKey="Frantz S">S. Frantz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, I" uniqKey="Gibson I">I. Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Groneberg, D A" uniqKey="Groneberg D">D.A. Groneberg</name></author><author><name sortKey="Witt, C" uniqKey="Witt C">C. Witt</name></author><author><name sortKey="Wagner, U" uniqKey="Wagner U">U. Wagner</name></author><author><name sortKey="Chung, K F" uniqKey="Chung K">K.F. Chung</name></author><author><name sortKey="Fischer, A" uniqKey="Fischer A">A. Fischer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Groneberg, D A" uniqKey="Groneberg D">D.A. Groneberg</name></author><author><name sortKey="Fischer, A" uniqKey="Fischer A">A. Fischer</name></author><author><name sortKey="Chung, K F" uniqKey="Chung K">K.F. Chung</name></author><author><name sortKey="Daniel, H" uniqKey="Daniel H">H. Daniel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T. Kuiken</name></author><author><name sortKey="Martina, B E" uniqKey="Martina B">B.E. Martina</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Rimmelzwaan, G F" uniqKey="Rimmelzwaan G">G.F. Rimmelzwaan</name></author><author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G. van Amerongen</name></author><author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D. van Riel</name></author><author><name sortKey="De Jong, T" uniqKey="De Jong T">T. de Jong</name></author><author><name sortKey="Itamura, S" uniqKey="Itamura S">S. Itamura</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Tashiro, M" uniqKey="Tashiro M">M. Tashiro</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, T Y" uniqKey="Ho T">T.Y. Ho</name></author><author><name sortKey="Wu, S L" uniqKey="Wu S">S.L. Wu</name></author><author><name sortKey="Chen, J C" uniqKey="Chen J">J.C. Chen</name></author><author><name sortKey="Wei, Y C" uniqKey="Wei Y">Y.C. Wei</name></author><author><name sortKey="Cheng, S E" uniqKey="Cheng S">S.E. Cheng</name></author><author><name sortKey="Chang, Y H" uniqKey="Chang Y">Y.H. Chang</name></author><author><name sortKey="Liu, H J" uniqKey="Liu H">H.J. Liu</name></author><author><name sortKey="Hsiang, C Y" uniqKey="Hsiang C">C.Y. Hsiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honda, K" uniqKey="Honda K">K. Honda</name></author><author><name sortKey="Yanai, H" uniqKey="Yanai H">H. Yanai</name></author><author><name sortKey="Negishi, H" uniqKey="Negishi H">H. Negishi</name></author><author><name sortKey="Asagiri, M" uniqKey="Asagiri M">M. Asagiri</name></author><author><name sortKey="Sato, M" uniqKey="Sato M">M. Sato</name></author><author><name sortKey="Mizutani, T" uniqKey="Mizutani T">T. Mizutani</name></author><author><name sortKey="Shimada, N" uniqKey="Shimada N">N. Shimada</name></author><author><name sortKey="Ohba, Y" uniqKey="Ohba Y">Y. Ohba</name></author><author><name sortKey="Takaoka, A" uniqKey="Takaoka A">A. Takaoka</name></author><author><name sortKey="Yoshida, N" uniqKey="Yoshida N">N. Yoshida</name></author><author><name sortKey="Taniguchi, T" uniqKey="Taniguchi T">T. Taniguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson Saliba, M" uniqKey="Johnson Saliba M">M. Johnson-Saliba</name></author><author><name sortKey="Jans, D A" uniqKey="Jans D">D.A. Jans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Judge, A D" uniqKey="Judge A">A.D. Judge</name></author><author><name sortKey="Sood, V" uniqKey="Sood V">V. Sood</name></author><author><name sortKey="Shaw, J R" uniqKey="Shaw J">J.R. Shaw</name></author><author><name sortKey="Fang, D" uniqKey="Fang D">D. Fang</name></author><author><name sortKey="Mcclintock, K" uniqKey="Mcclintock K">K. McClintock</name></author><author><name sortKey="Maclachlan, I" uniqKey="Maclachlan I">I. MacLachlan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamitani, W" uniqKey="Kamitani W">W. Kamitani</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name></author><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K. Narayanan</name></author><author><name sortKey="Lokugamage, K G" uniqKey="Lokugamage K">K.G. Lokugamage</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S. Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katze, M G" uniqKey="Katze M">M.G. Katze</name></author><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name></author><author><name sortKey="Oberste, M S" uniqKey="Oberste M">M.S. Oberste</name></author><author><name sortKey="Monroe, S S" uniqKey="Monroe S">S.S. Monroe</name></author><author><name sortKey="Nix, W A" uniqKey="Nix W">W.A. Nix</name></author><author><name sortKey="Campagnoli, R" uniqKey="Campagnoli R">R. Campagnoli</name></author><author><name sortKey="Icenogle, J P" uniqKey="Icenogle J">J.P. Icenogle</name></author><author><name sortKey="Penaranda, S" uniqKey="Penaranda S">S. Penaranda</name></author><author><name sortKey="Bankamp, B" uniqKey="Bankamp B">B. Bankamp</name></author><author><name sortKey="Maher, K" uniqKey="Maher K">K. Maher</name></author><author><name sortKey="Chen, M H" uniqKey="Chen M">M.H. Chen</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S. Tong</name></author><author><name sortKey="Tamin, A" uniqKey="Tamin A">A. Tamin</name></author><author><name sortKey="Lowe, L" uniqKey="Lowe L">L. Lowe</name></author><author><name sortKey="Frace, M" uniqKey="Frace M">M. Frace</name></author><author><name sortKey="Derisi, J L" uniqKey="Derisi J">J.L. DeRisi</name></author><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q. Chen</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author><author><name sortKey="Erdman, D D" uniqKey="Erdman D">D.D. Erdman</name></author><author><name sortKey="Peret, T C" uniqKey="Peret T">T.C. Peret</name></author><author><name sortKey="Burns, C" uniqKey="Burns C">C. Burns</name></author><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author><author><name sortKey="Rollin, P E" uniqKey="Rollin P">P.E. Rollin</name></author><author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A. Sanchez</name></author><author><name sortKey="Liffick, S" uniqKey="Liffick S">S. Liffick</name></author><author><name sortKey="Holloway, B" uniqKey="Holloway B">B. Holloway</name></author><author><name sortKey="Limor, J" uniqKey="Limor J">J. Limor</name></author><author><name sortKey="Mccaustland, K" uniqKey="Mccaustland K">K. McCaustland</name></author><author><name sortKey="Olsen Rasmussen, M" uniqKey="Olsen Rasmussen M">M. Olsen-Rasmussen</name></author><author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R. Fouchier</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Pallansch, M A" uniqKey="Pallansch M">M.A. Pallansch</name></author><author><name sortKey="Anderson, L J" uniqKey="Anderson L">L.J. Anderson</name></author><author><name sortKey="Bellini, W J" uniqKey="Bellini W">W.J. Bellini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kopecky Bromberg, S A" uniqKey="Kopecky Bromberg S">S.A. Kopecky-Bromberg</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author><author><name sortKey="Frieman, M" uniqKey="Frieman M">M. Frieman</name></author><author><name sortKey="Baric, R A" uniqKey="Baric R">R.A. Baric</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D. Erdman</name></author><author><name sortKey="Goldsmith, C S" uniqKey="Goldsmith C">C.S. Goldsmith</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S.R. Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T. Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S. Emery</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S. Tong</name></author><author><name sortKey="Urbani, C" uniqKey="Urbani C">C. Urbani</name></author><author><name sortKey="Comer, J A" uniqKey="Comer J">J.A. Comer</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Rollin, P E" uniqKey="Rollin P">P.E. Rollin</name></author><author><name sortKey="Dowell, S F" uniqKey="Dowell S">S.F. Dowell</name></author><author><name sortKey="Ling, A E" uniqKey="Ling A">A.E. Ling</name></author><author><name sortKey="Humphrey, C D" uniqKey="Humphrey C">C.D. Humphrey</name></author><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W.J. Shieh</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J. Guarner</name></author><author><name sortKey="Paddock, C D" uniqKey="Paddock C">C.D. Paddock</name></author><author><name sortKey="Rota, P" uniqKey="Rota P">P. Rota</name></author><author><name sortKey="Fields, B" uniqKey="Fields B">B. Fields</name></author><author><name sortKey="Derisi, J" uniqKey="Derisi J">J. DeRisi</name></author><author><name sortKey="Yang, J Y" uniqKey="Yang J">J.Y. Yang</name></author><author><name sortKey="Cox, N" uniqKey="Cox N">N. Cox</name></author><author><name sortKey="Hughes, J M" uniqKey="Hughes J">J.M. Hughes</name></author><author><name sortKey="Leduc, J W" uniqKey="Leduc J">J.W. LeDuc</name></author><author><name sortKey="Bellini, W J" uniqKey="Bellini W">W.J. Bellini</name></author><author><name sortKey="Anderson, L J" uniqKey="Anderson L">L.J. Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumaki, Y" uniqKey="Kumaki Y">Y. Kumaki</name></author><author><name sortKey="Day, C W" uniqKey="Day C">C.W. Day</name></author><author><name sortKey="Wandersee, M K" uniqKey="Wandersee M">M.K. Wandersee</name></author><author><name sortKey="Schow, B P" uniqKey="Schow B">B.P. Schow</name></author><author><name sortKey="Madsen, J S" uniqKey="Madsen J">J.S. Madsen</name></author><author><name sortKey="Grant, D" uniqKey="Grant D">D. Grant</name></author><author><name sortKey="Roth, J P" uniqKey="Roth J">J.P. Roth</name></author><author><name sortKey="Smee, D F" uniqKey="Smee D">D.F. Smee</name></author><author><name sortKey="Blatt, L M" uniqKey="Blatt L">L.M. Blatt</name></author><author><name sortKey="Barnard, D L" uniqKey="Barnard D">D.L. Barnard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumaki, Y" uniqKey="Kumaki Y">Y. Kumaki</name></author><author><name sortKey="Day, C W" uniqKey="Day C">C.W. Day</name></author><author><name sortKey="Bailey, K W" uniqKey="Bailey K">K.W. Bailey</name></author><author><name sortKey="Wandersee, M K" uniqKey="Wandersee M">M.K. Wandersee</name></author><author><name sortKey="Wong, M H" uniqKey="Wong M">M.H. Wong</name></author><author><name sortKey="Madsen, J R" uniqKey="Madsen J">J.R. Madsen</name></author><author><name sortKey="Madsen, J S" uniqKey="Madsen J">J.S. Madsen</name></author><author><name sortKey="Nelson, N M" uniqKey="Nelson N">N.M. Nelson</name></author><author><name sortKey="Hoopes, J D" uniqKey="Hoopes J">J.D. Hoopes</name></author><author><name sortKey="Woolcott, J D" uniqKey="Woolcott J">J.D. Woolcott</name></author><author><name sortKey="Mclean, T Z" uniqKey="Mclean T">T.Z. McLean</name></author><author><name sortKey="Blatt, L M" uniqKey="Blatt L">L.M. Blatt</name></author><author><name sortKey="Salazar, A M" uniqKey="Salazar A">A.M. Salazar</name></author><author><name sortKey="Smee, D F" uniqKey="Smee D">D.F. Smee</name></author><author><name sortKey="Barnard, D L" uniqKey="Barnard D">D.L. Barnard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuri, T" uniqKey="Kuri T">T. Kuri</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Habjan, M" uniqKey="Habjan M">M. Habjan</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name></author><author><name sortKey="Yuan, Z" uniqKey="Yuan Z">Z. Yuan</name></author><author><name sortKey="Weber, F" uniqKey="Weber F">F. Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leonard, J N" uniqKey="Leonard J">J.N. Leonard</name></author><author><name sortKey="Schaffer, D V" uniqKey="Schaffer D">D.V. Schaffer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, R" uniqKey="Lin R">R. Lin</name></author><author><name sortKey="Heylbroeck, C" uniqKey="Heylbroeck C">C. Heylbroeck</name></author><author><name sortKey="Pitha, P M" uniqKey="Pitha P">P.M. Pitha</name></author><author><name sortKey="Hiscott, J" uniqKey="Hiscott J">J. Hiscott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loutfy, M R" uniqKey="Loutfy M">M.R. Loutfy</name></author><author><name sortKey="Blatt, L M" uniqKey="Blatt L">L.M. Blatt</name></author><author><name sortKey="Siminovitch, K A" uniqKey="Siminovitch K">K.A. Siminovitch</name></author><author><name sortKey="Ward, S" uniqKey="Ward S">S. Ward</name></author><author><name sortKey="Wolff, B" uniqKey="Wolff B">B. Wolff</name></author><author><name sortKey="Lho, H" uniqKey="Lho H">H. Lho</name></author><author><name sortKey="Pham, D H" uniqKey="Pham D">D.H. Pham</name></author><author><name sortKey="Deif, H" uniqKey="Deif H">H. Deif</name></author><author><name sortKey="Lamere, E A" uniqKey="Lamere E">E.A. LaMere</name></author><author><name sortKey="Chang, M" uniqKey="Chang M">M. Chang</name></author><author><name sortKey="Kain, K C" uniqKey="Kain K">K.C. Kain</name></author><author><name sortKey="Farcas, G A" uniqKey="Farcas G">G.A. Farcas</name></author><author><name sortKey="Ferguson, P" uniqKey="Ferguson P">P. Ferguson</name></author><author><name sortKey="Latchford, M" uniqKey="Latchford M">M. Latchford</name></author><author><name sortKey="Levy, G" uniqKey="Levy G">G. Levy</name></author><author><name sortKey="Dennis, J W" uniqKey="Dennis J">J.W. Dennis</name></author><author><name sortKey="Lai, E K" uniqKey="Lai E">E.K. Lai</name></author><author><name sortKey="Fish, E N" uniqKey="Fish E">E.N. Fish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Pan, J" uniqKey="Pan J">J. Pan</name></author><author><name sortKey="Tao, J" uniqKey="Tao J">J. Tao</name></author><author><name sortKey="Guo, D" uniqKey="Guo D">D. Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paragas, J" uniqKey="Paragas J">J. Paragas</name></author><author><name sortKey="Blatt, L M" uniqKey="Blatt L">L.M. Blatt</name></author><author><name sortKey="Hartmann, C" uniqKey="Hartmann C">C. Hartmann</name></author><author><name sortKey="Huggins, J W" uniqKey="Huggins J">J.W. Huggins</name></author><author><name sortKey="Endy, T P" uniqKey="Endy T">T.P. Endy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S.T. Lai</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Yam, L Y" uniqKey="Yam L">L.Y. Yam</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J. Nicholls</name></author><author><name sortKey="Yee, W K" uniqKey="Yee W">W.K. Yee</name></author><author><name sortKey="Yan, W W" uniqKey="Yan W">W.W. Yan</name></author><author><name sortKey="Cheung, M T" uniqKey="Cheung M">M.T. Cheung</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Tsang, D N" uniqKey="Tsang D">D.N. Tsang</name></author><author><name sortKey="Yung, R W" uniqKey="Yung R">R.W. Yung</name></author><author><name sortKey="Ng, T K" uniqKey="Ng T">T.K. Ng</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name></author><author><name sortKey="Deming, D" uniqKey="Deming D">D. Deming</name></author><author><name sortKey="Paddock, C D" uniqKey="Paddock C">C.D. Paddock</name></author><author><name sortKey="Cheng, A" uniqKey="Cheng A">A. Cheng</name></author><author><name sortKey="Yount, B" uniqKey="Yount B">B. Yount</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L. Vogel</name></author><author><name sortKey="Herman, B D" uniqKey="Herman B">B.D. Herman</name></author><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T. Sheahan</name></author><author><name sortKey="Heise, M" uniqKey="Heise M">M. Heise</name></author><author><name sortKey="Genrich, G L" uniqKey="Genrich G">G.L. Genrich</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S.R. Zaki</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R. Baric</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockx, B" uniqKey="Rockx B">B. Rockx</name></author><author><name sortKey="Baas, T" uniqKey="Baas T">T. Baas</name></author><author><name sortKey="Zornetzer, G A" uniqKey="Zornetzer G">G.A. Zornetzer</name></author><author><name sortKey="Haagmans, B" uniqKey="Haagmans B">B. Haagmans</name></author><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T. Sheahan</name></author><author><name sortKey="Frieman, M" uniqKey="Frieman M">M. Frieman</name></author><author><name sortKey="Dyer, M D" uniqKey="Dyer M">M.D. Dyer</name></author><author><name sortKey="Teal, T H" uniqKey="Teal T">T.H. Teal</name></author><author><name sortKey="Proll, S" uniqKey="Proll S">S. Proll</name></author><author><name sortKey="Van Den Brand, J" uniqKey="Van Den Brand J">J. van den Brand</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sidwell, R W" uniqKey="Sidwell R">R.W. Sidwell</name></author><author><name sortKey="Bailey, K W" uniqKey="Bailey K">K.W. Bailey</name></author><author><name sortKey="Wong, M H" uniqKey="Wong M">M.H. Wong</name></author><author><name sortKey="Huffman, J H" uniqKey="Huffman J">J.H. Huffman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smits, S L" uniqKey="Smits S">S.L. Smits</name></author><author><name sortKey="De Lang, A" uniqKey="De Lang A">A. de Lang</name></author><author><name sortKey="Van Den Brand, J M A" uniqKey="Van Den Brand J">J.M.A. van den Brand</name></author><author><name sortKey="Leijten, L M" uniqKey="Leijten L">L.M. Leijten</name></author><author><name sortKey="Van Ijcken, W F" uniqKey="Van Ijcken W">W.F. van Ijcken</name></author><author><name sortKey="Eijkemans, M J C" uniqKey="Eijkemans M">M.J.C. Eijkemans</name></author><author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G. van Amerongen</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T. Kuiken</name></author><author><name sortKey="Andeweg, A C" uniqKey="Andeweg A">A.C. Andeweg</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A.D.M.E. Osterhaus</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spiegel, M" uniqKey="Spiegel M">M. Spiegel</name></author><author><name sortKey="Pichlmair, A" uniqKey="Pichlmair A">A. Pichlmair</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L. Martinez-Sobrido</name></author><author><name sortKey="Cros, J" uniqKey="Cros J">J. Cros</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name></author><author><name sortKey="Haller, O" uniqKey="Haller O">O. Haller</name></author><author><name sortKey="Weber, F" uniqKey="Weber F">F. Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stroher, U" uniqKey="Stroher U">U. Ströher</name></author><author><name sortKey="Dicaro, A" uniqKey="Dicaro A">A. DiCaro</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Strong, J E" uniqKey="Strong J">J.E. Strong</name></author><author><name sortKey="Aoki, F" uniqKey="Aoki F">F. Aoki</name></author><author><name sortKey="Plummer, F" uniqKey="Plummer F">F. Plummer</name></author><author><name sortKey="Jones, S M" uniqKey="Jones S">S.M. Jones</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H. Feldmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Mcauliffe, J" uniqKey="Mcauliffe J">J. McAuliffe</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L. Vogel</name></author><author><name sortKey="Fahle, G" uniqKey="Fahle G">G. Fahle</name></author><author><name sortKey="Fischer, S" uniqKey="Fischer S">S. Fischer</name></author><author><name sortKey="Tatti, K" uniqKey="Tatti K">K. Tatti</name></author><author><name sortKey="Packard, M" uniqKey="Packard M">M. Packard</name></author><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W.J. Shieh</name></author><author><name sortKey="Zaki, S" uniqKey="Zaki S">S. Zaki</name></author><author><name sortKey="Murphy, B" uniqKey="Murphy B">B. Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J. Sui</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Murakami, A" uniqKey="Murakami A">A. Murakami</name></author><author><name sortKey="Tamin, A" uniqKey="Tamin A">A. Tamin</name></author><author><name sortKey="Matthews, L J" uniqKey="Matthews L">L.J. Matthews</name></author><author><name sortKey="Wong, S K" uniqKey="Wong S">S.K. Wong</name></author><author><name sortKey="Moore, M J" uniqKey="Moore M">M.J. Moore</name></author><author><name sortKey="Tallarico, A S" uniqKey="Tallarico A">A.S. Tallarico</name></author><author><name sortKey="Olurinde, M" uniqKey="Olurinde M">M. Olurinde</name></author><author><name sortKey="Choe, H" uniqKey="Choe H">H. Choe</name></author><author><name sortKey="Anderson, L J" uniqKey="Anderson L">L.J. Anderson</name></author><author><name sortKey="Bellini, W J" uniqKey="Bellini W">W.J. Bellini</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M. Farzan</name></author><author><name sortKey="Marasco, W A" uniqKey="Marasco W">W.A. Marasco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, E L" uniqKey="Tan E">E.L. Tan</name></author><author><name sortKey="Ooi, E E" uniqKey="Ooi E">E.E. Ooi</name></author><author><name sortKey="Lin, C Y" uniqKey="Lin C">C.Y. Lin</name></author><author><name sortKey="Tan, H C" uniqKey="Tan H">H.C. Tan</name></author><author><name sortKey="Ling, A E" uniqKey="Ling A">A.E. Ling</name></author><author><name sortKey="Lim, B" uniqKey="Lim B">B. Lim</name></author><author><name sortKey="Stanton, L W" uniqKey="Stanton L">L.W. Stanton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weaver, E A" uniqKey="Weaver E">E.A. Weaver</name></author><author><name sortKey="Barry, M A" uniqKey="Barry M">M.A. Barry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, J Q" uniqKey="Wu J">J.Q. Wu</name></author><author><name sortKey="Barabe, N D" uniqKey="Barabe N">N.D. Barabe</name></author><author><name sortKey="Huang, Y M" uniqKey="Huang Y">Y.M. Huang</name></author><author><name sortKey="Rayner, G A" uniqKey="Rayner G">G.A. Rayner</name></author><author><name sortKey="Christopher, M E" uniqKey="Christopher M">M.E. Christopher</name></author><author><name sortKey="Schmaltz, F L" uniqKey="Schmaltz F">F.L. Schmaltz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name></author><author><name sortKey="Yang, M" uniqKey="Yang M">M. Yang</name></author><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Lou, Z" uniqKey="Lou Z">Z. Lou</name></author><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z. Zhou</name></author><author><name sortKey="Sun, L" uniqKey="Sun L">L. Sun</name></author><author><name sortKey="Mo, L" uniqKey="Mo L">L. Mo</name></author><author><name sortKey="Ye, S" uniqKey="Ye S">S. Ye</name></author><author><name sortKey="Pang, H" uniqKey="Pang H">H. Pang</name></author><author><name sortKey="Gao, G F" uniqKey="Gao G">G.F. Gao</name></author><author><name sortKey="Anand, K" uniqKey="Anand K">K. Anand</name></author><author><name sortKey="Bartlam, M" uniqKey="Bartlam M">M. Bartlam</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author><author><name sortKey="Rao, Z" uniqKey="Rao Z">Z. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, B" uniqKey="Zheng B">B. Zheng</name></author><author><name sortKey="He, M L" uniqKey="He M">M.L. He</name></author><author><name sortKey="Wong, K L" uniqKey="Wong K">K.L. Wong</name></author><author><name sortKey="Lum, C T" uniqKey="Lum C">C.T. Lum</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Peng, Y" uniqKey="Peng Y">Y. Peng</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Lin, M C" uniqKey="Lin M">M.C. Lin</name></author><author><name sortKey="Kung, H F" uniqKey="Kung H">H.F. Kung</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Utah</li></region></list><tree><country name="États-Unis"><region name="Utah"><name sortKey="Kumaki, Yohichi" sort="Kumaki, Yohichi" uniqKey="Kumaki Y" first="Yohichi" last="Kumaki">Yohichi Kumaki</name></region><name sortKey="Bailey, Kevin W" sort="Bailey, Kevin W" uniqKey="Bailey K" first="Kevin W." last="Bailey">Kevin W. Bailey</name><name sortKey="Barnard, Dale L" sort="Barnard, Dale L" uniqKey="Barnard D" first="Dale L." last="Barnard">Dale L. Barnard</name><name sortKey="Li, Joseph K K" sort="Li, Joseph K K" uniqKey="Li J" first="Joseph K.-K." last="Li">Joseph K.-K. Li</name><name sortKey="Madsen, Jason R" sort="Madsen, Jason R" uniqKey="Madsen J" first="Jason R." last="Madsen">Jason R. Madsen</name><name sortKey="Smith, Aaron J" sort="Smith, Aaron J" uniqKey="Smith A" first="Aaron J." last="Smith">Aaron J. Smith</name><name sortKey="Vest, Zachary G" sort="Vest, Zachary G" uniqKey="Vest Z" first="Zachary G." last="Vest">Zachary G. Vest</name><name sortKey="Wandersee, Miles K" sort="Wandersee, Miles K" uniqKey="Wandersee M" first="Miles K." last="Wandersee">Miles K. Wandersee</name></country><country name="Canada"><noRegion><name sortKey="Ennis, Jane" sort="Ennis, Jane" uniqKey="Ennis J" first="Jane" last="Ennis">Jane Ennis</name></noRegion><name sortKey="Rahbar, Ramtin" sort="Rahbar, Ramtin" uniqKey="Rahbar R" first="Ramtin" last="Rahbar">Ramtin Rahbar</name><name sortKey="Turner, Jeffrey D" sort="Turner, Jeffrey D" uniqKey="Turner J" first="Jeffrey D." last="Turner">Jeffrey D. Turner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002447 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002447 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3018546
|texte= Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21093489" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |